Anti-Smad3 Polyclonal Antibody-抗体-抗体-生物在线

Anti-Smad3 Polyclonal Antibody

产品名称： Anti-Smad3 Polyclonal Antibody

英文名称： DKFZP586N0721;DKFZp686J10186;hMAD 3;hMAD-3;hSMAD3;HSPC193;HST17436;JV15 2;JV15-2;JV152;LDS1C;LDS3;MAD (mothers against decapentaplegic Drosophila) hom

产品编号： K108967P

产品价格： null

产品产地：北京

品牌商标：

更新时间： 2025-02-10T13:37:45

使用范围： WB

北京索莱宝科技有限公司

联系人 : 索莱宝-龚思雨
地址 : 北京市通州区中关村科技园区通州园金桥科技产业基地景盛南四街15号85A三层
邮编 : 101102
所在区域 : 北京
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产品详情

产品简介
英文名称 Anti-Smad3 Polyclonal Antibody
宿主 Rabbit
别名 DKFZP586N0721;DKFZp686J10186;hMAD 3;hMAD-3;hSMAD3;HSPC193;HST17436;JV15 2;JV15-2;JV152;LDS1C;LDS3;MAD (mothers against decapentaplegic Drosophila) homolog 3;MAD homolog 3;Mad homolog JV15 2;Mad protein homolog;MAD, mothers against decapentaplegic homolog 3;Mad3;MADH 3;MADH3;MGC60396;Mothers against decapentaplegic homolog 3;Mothers against DPP homolog 3;SMA and MAD related protein 3;SMAD 3;SMAD;SMAD family member 3;SMAD, mothers against DPP homolog 3;Smad3;SMAD3_HUMAN;
稀释比例 WB 1:1000-3000. IF 1:50-200.
蛋白分子量 26/36/43/48kDa
Gene ID 4088
保存 Store at -20°C. Avoid freeze / thaw cycles.
储存液 Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法 Octanoic acid-ammonium sulfate precipitation
亚型 IgG
免疫原 A synthetic peptide of human Smad3
亚细胞定位 Cytoplasm
Swiss Prot P84022
背景资料 Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Public Immunogen Range 190-240/425aa
克隆类型 Polyclonal Antibody
交叉反应 Human Rat Mouse
应用 WB IF
规格 50ul 100ul
 
备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
实验图
Western blot analysis with Smad3 antibody diluted at 1:2000;Lane:Jurkat,HT29,293T,Rat brain

英文名称	Anti-Smad3 Polyclonal Antibody
宿主	Rabbit
别名	DKFZP586N0721;DKFZp686J10186;hMAD 3;hMAD-3;hSMAD3;HSPC193;HST17436;JV15 2;JV15-2;JV152;LDS1C;LDS3;MAD (mothers against decapentaplegic Drosophila) homolog 3;MAD homolog 3;Mad homolog JV15 2;Mad protein homolog;MAD, mothers against decapentaplegic homolog 3;Mad3;MADH 3;MADH3;MGC60396;Mothers against decapentaplegic homolog 3;Mothers against DPP homolog 3;SMA and MAD related protein 3;SMAD 3;SMAD;SMAD family member 3;SMAD, mothers against DPP homolog 3;Smad3;SMAD3_HUMAN;
稀释比例	WB 1:1000-3000. IF 1:50-200.
蛋白分子量	26/36/43/48kDa
Gene ID	4088
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法	Octanoic acid-ammonium sulfate precipitation
亚型	IgG
免疫原	A synthetic peptide of human Smad3
亚细胞定位	Cytoplasm
Swiss Prot	P84022
背景资料	Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Public Immunogen Range	190-240/425aa
克隆类型	Polyclonal Antibody
交叉反应	Human Rat Mouse
应用	WB IF
规格	50ul 100ul